A combination of high-resolution MRI ( magnetic resonance imaging) and functional MRI images gave researchers an unprecedented look at the cortex. They couldn’t have asked for better data. The team began with nearly 450 different brain scans from young, healthy volunteers recruited by the Human Connectome Project. In other words, what variables should a brain mapper use to optimally partition a brain? In this study, Glasser and colleagues offered one solution.
What kinds of chemicals do neurons use to talk to each other? How do neurons connect, both within their immediate vicinity and with regions far off? How do their computations differ?
Part of the reason why brain mapping stagnated is because it’s seriously tough business.Įvery location in the brain can be described by hundreds, if not thousands, of parameters. “Believe it or not, this has remained the standard in the brain imaging field,” first author Dr. Yet later research found that Brodmann was incredibly on point: his areas correlated surprisingly well with discrete brain functions - sight, smell, sensations, movement and so on - giving serious credence to biology’s mantra of “function follows form.” Based solely on their organization, he delineated the cortex into 52 distinctive areas. Unlike his predecessors, the German anatomist Korbinian Brodmann carefully observed how brain cells are laid out across the cortex, paying no particular mind to their function. Perhaps the most famous brain map to date is Brodmann’s map, first published in 1909. If injury to one brain area caused a speech deficit, for example, that region was assumed to be responsible for at least one aspect of speech. Historical Maps: Old, But Far From ObsoleteĮfforts to map the brain started long before the birth of modern neuroscience.Įarly cartographers mostly relied on observations of surgeries and brain injuries to parse the cortex into distinct regions. That’s the promise of this new map: a long-awaited, authoritative framework that lets scientists pinpoint exactly where they are in any given human brain. And that’s a problem: how can scientists compare data if they aren’t even sure they’re looking at the same spot? By all measures, our current brain map is far too simple. To many, the cortex represents the seat of human intelligence: not only does it process information from our various senses, it also drives higher cognitive functions, such as planning, strategy and self-control.Īlthough scientists have long mapped the structural landscape of the cortex, how it functionally organizes into regions has thus far escaped brain cartographers. As the outermost layer of the brain, the cortex is perhaps the most easily identifiable structure, with its surface carved by many hills and valleys into distinctive patterns. This week, researchers at Washington University published the “ most intricate” map of the human cortex to date. One that takes us into the uncharted territories of the mysterious three-pound organ that underlies our thoughts, emotions, hopes and dreams: the human brain. Now, thanks to a new - if slightly different - type of map, we may be approaching a new age of discovery. They began charting new worlds, and in turn, made newer maps that helped future generations better understand the lands and seas that cover our world.
To me, maps always conjure up a sense of exploration.īack in the Age of Discovery, rudimentary maps allowed European explorers to sail into the vast unknown.